ABSTRACT
Objective To investigate the effect of atorvastatin on serum levels of inflammatory cytokines,pulmonary function and right ventricular remodeling in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension.Methods From December 2013 to December 2016,106 patients with COPD complicated with pulmonary hypertension were randomly divided into treatment and control groups,each with 53 cases.Patients in control group were treated with routine basic therapy for three months,and patients in treatment group were treated with atorvastatin on the basis of control group.The pulmonary function,right ventricular remodeling function and inflammatory factors were detected,and the clinical efficacy of two groups was evaluated.Results The total effective rate was 94.34％ in the treatment group and 79.25％ in the control group,difference between the two groups was significant (P ＜ 0.05).The levels of FEV1 and FVC were not significantly different between two groups before treatment.The levels of FVC and FEV1 in treatment group were significantly higher than those in the control group after treatment (P ＜ 0.05).After treatment,the LVED,LVPW,TRVmax and RVEF of treatment group were significantly higher than those of control group (P ＜ 0.05),and the difference was statistically significant.Compared with before treatment,LVID,LVPW and TRVmax were increased,RVAD decreased,and the difference was statistically significant (P ＜ 0.05).The levels of CRP,ET and IL-6 in the treatment group were significantly lower than those in the control group (P ＜ 0.05),and difference was statistically significant.Conclusion The effect of atorvastatin on serum inflammatory factors,pulmonary function and right ventricular remodeling in patients with COPD combined with pulmonary hypertension is significant and can be popularized.
ABSTRACT
Objective To investigate the clinical effect of fasudil in heart failure induced by chronic pneumocardial disease and the influence in serum level of NO and ET-1.Methods 100 cases of patients with heart failure induced by chronic pneumocardial disease in our hospital from September 2013 to September 2016 were selected and divided into observation group and control group,50 cases in each group.Patients in the control group were treated with conventional therapy,and in the observation group were treated with fasudil based on the conventional therapy.Compared the clinical effect,blood oxygen partial pressure (PaO2),CO2 partial pressure (PaCO2),tricuspid regurgitation speed,fight ventricular outflow tract inside diameter(RVOT),left ventricular ejection fraction (LVEF) and serum biochemical indexes (NO and ET-1) levels.Results After treatment,the total effective rate of the observation group was significantly higher than control group (P ＜ 0.05).PaO2,LVEF,serum level of NO of the two groups were significantly higher,PaCO2,tricuspid regurgitation speed,RVOT,serum level of ET-1 significantly lower than before treatment (P ＜ 0.05),and the PaO2,LVEF,serum level of NO of observation group were significantly higher,PaCO2,tricuspid regurgitation speed,RVOT,serum level of ET-1 of observation group were significantly lower than control group (P ＜ 0.05).Conclusion Fasudil had remarkable clinical effect in heart failure induced by chronic pneumocardial disease,and improve the patient's clinical symptoms,adjust the serum level of NO and ET-1.